Hans-Heiner Gorris

Academic studies and career:

1994 - 2001 Diploma in Biology, University of Münster (Germany) and University of York (England)

2001 - 2005 PhD, University of Lübeck (Germany)

2006 - 2009 Postdoctoral Fellow, Department of Chemistry, Tufts University, Medford (USA)

since 2009 Assistant Professor at the Institute of Analytical Chemistry, Chemo- und Biosensors, University of Regensburg (Germany); habilitation in 201

 

Research interests:

(1) Femtoliter Arrays: Single molecule analysis of enzyme kinetics; multiplexed assays.

(2) Upconverting nanoparticles: Background-free luminescent labeling for bioassays and bioimaging; Ratiometric encoding strategies.

(3) Luminescent sensing: Ratiometric measurements of enzyme activities, oxygen and other (bio-)analytes.

Awards and memberships:

(1) Heisenberg Fellowship of the German Research Council (2016-2018).

(2) Chair of the "European Upconversion Network" (COST Action CM1403), a transnational consortium of 22 European countries.

Selected publications:

(1) Liebherr RB, Renner M, Gorris HH (2014): A single molecule perspective on the functi­onal diversity of in vitro-evolved β-glucuronidase. JACS 136, 5949-5955.

(2) Hlaváček A, Sedlmeier A, Skládal, P, Gorris HH (2014): Electrophoretic characterization and purification of silica-coated photon-upconverting nanoparticles and their bioconju­gates. ACS Appl. Mater. Interfaces 6, 6930-6935.

(3) Gorris HH, Ali R, Saleh SM, Wolfbeis OS (2011): Tuning the dual emission of photon-upconverting nanoparticles for ratiometric multiplexed encoding. Adv. Mater. 23, 1652-1655.

(4) Gorris HH, Walt DR (2009): Mechanistic aspects of horseradish peroxidase elucidated through single-molecule studies. JACS 131, 6277-6282.

(5) Gorris HH, Rissin DM, Walt DR (2007): Stochastic inhibitor release and binding from single-enzyme molecules. PNAS 104, 17680-17685.

 

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