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Laboratory of Nanoparticles for Biomedicine, Moscow State University, Moscow/Russian Federation

Prof. Dr. Victor Timoshenko

Physics Department

M.V. Lomonosov Moscow State University

Leninskie Gory 1, Bld. 35

Phone: +7(495) 9394681

Fax: +7(495) 9394681

E-mail: timoshen(at)physics.msu.ru

Recent Activity

NB-Lab is focused on formation and investigation of nontoxic solid state nanoparticles (NPs) with tailored properties for applications in biophotonics, biosensorics and biomedicine. Silicon (Si) based NPs prepared from porous silicon are explored as efficient photo- and sonosensitazers for therapy of cancer both in vitro and in vivo. Highly luminescent Si NPs are produced and investigated as labels for bioimaging applications and UV protection of human skin. Antiviral effect of SiNP has been found and investigated.

Silicon nanowires (SiNWs) with mean diameters in the range of 20-100 nm are grown by metal-assisted chemical etching of crystalline Si. The length of SiNWs in the range from 50 to 500 nm is controlled by the etching time. The surface of SiNWs can be covered by thin (10-20 nm) layer of small Si nanocrystals (NCs) by using post-etching in redox solutions (stain etching). SiNWs are detached from the Si substrate and dispersed in water by ultrasound irradiation. SiNPs and SiNWs dispersed in water and biological liquids (simulated body fluid, blood serum, phosphate buffer, etc.) were investigated for their cytotoxicity and biodegradability. The diagnostic part of theranostic applications of SiNPs and SiNWs is explored by using their photoluminescent (PL) and electrical properties. The PL properties of SiNWs are ensured by small SiNCs on the surface of nanowires. The prepared aqueous suspensions of luminescent SiNPs and SiNWs are used for bioimaging experiments. The properties of SiNCs and SiNWs as luminescent labels for cancer cells are explored. The electrical impedance of SiNWs is investigated for biosensing applications.

Personnel

1. Victor Timoshenko, Prof. Dr. Sci. (Head of NB-Lab)

2. Liubov Osminkina, Dr. (Vice-Head of NB-Lab)

3. Andrei Kudryavtcev, Dr. (Senior Researcher) - ITEB, Pushino

4. Maxim Gongalsky, Dr. (Post Doc, Researcher)

5. Kirill Gonchar, M.S. (Researcher)

6. Andrey Sviridov, Ph.D. Student

7. Konstantin Tamarov, Ph.D. Student

8. Yulia Kargina, Ph.D. Student

9. Svetlana N. Shevchenko, Ph.D. Student

10. Tatiana Yu. Bazylenko (Engineer)

Equipment and Methods

1. Equipment for chemical and electrochemical nanostructuring of materials

2. Planetary Ball Mill "Pulviresette 7" Premium Line (Fritsch) for mechanical nanostructuring of materials

3. Powerful lasers for ablation and nanoparticles formation

4. Set-up for cell growth and biomedical experiments in vitro (Puschino, IETB RAS)

5. Equipment for optical spectroscopy and microscopy of materials

6. FTIR, photoluminescence and Raman spectroscopy

Selected Papers

1. M.B. Gongalsky, A.Yu Kharin, S.A. Zagorodskikh, L.A. Osminkina, V.Yu Timoshenko. Photosensitized generation of singlet oxygen in porous silicon studied by simultaneous measurements of luminescence of nanocrystals and oxygen molecules. Journal of Applied Physics, 110(1):013707-1-013707-5 (2011).

2. K. Abderrafi, Calzada R. García, M.B. Gongalsky, I. Suárez, R. Abarques, V.S. Chirvony, V.Y. Timoshenko, R. Ibáñez, J.P. Martínez-Pastor. Silicon nanocrystals produced by nanosecond laser ablation in an organic liquid. Journal of Physical Chemistry C, 115(12):5147-5151 (2011).

3. L.A. Osminkina, M.B. Gongalsky, A.V. Motuzuk, V.Y. Timoshenko, A.A. Kudryavtsev. Silicon nanocrystals as photo- and sono-sensitizers for biomedical applications. Applied Physics B: Lasers and Optics, 105(3):665-668 (2011).

4. L.A. Osminkina, K.P. Tamarov, A.P. Sviridov, R.A. Galkin, M.B. Gongalsky, V.V. Solovyev, A.A. Kudryavtsev, V.Yu Timoshenko. Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications. Journal of Biophotonics, Vol. 5, Iss. 7, 529-535 (2012).

5. L.A. Osminkina, K.A. Gonchar, V.S. Marshov, K.V. Bunkov, D.V. Petrov, L.A. Golovan, F. Talkenberg, V.A. Sivakov, V.Yu Timoshenko. Optical properties of silicon nanowire arrays formed by metal-assisted chemical etching: evidences for light localization effect. Nanoscale Research Letters, 7(524):1-6 (2012).

6. A. V. Pavlikov, A. V. Lartsev, I. A. Gayduchenko, V. Yu Timoshenko. Optical properties of materials based on oxidized porous silicon and their applications for UV protection. Microelectronic Engineering, 90(0):96-98 (2012).

7. M.B. Gongalsky, A.Yu Kharin, L.A. Osminkina, V.Yu Timoshenko, J.J. Jeong, H. Lee, B.H. Chung. Enhanced photoluminescence of porous silicon nanoparticles coated by bioresorbable polymers. Nanoscale Research Letters, 7(446):1-7 (2012).

8. L.A. Golovan, K.A. Gonchar, L.A. Osminkina, V.Yu Timoshenko, G.I. Petrov, and V.V. Yakovlev. Coherent anti-stokes Raman scattering in silicon nanowire ensembles. Laser Physics Letters, 9(2):145-150 (2012).

9. S.A. Dyakov, D.M. Zhigunov, A. Hartel, M. Zacharias, T.S. Perova, V.Y. Timoshenko. Enhancement of photoluminescence signal from ultrathin layers with silicon nanocrystals. Applied Physics Letters, 100(6):061908-1-061908-4 (2012).

10. K.A. Gonchar, L.A. Osminkina, R.A. Galkin, V.S. Marshov, D.V. Petrov, V.V. Solovyev, A.A. Kudryavtsev, V.A. Sivakov, V.Yu Timoshenko. Structure and optical properties of silicon nanowire arrays formed by metal-assisted chemical etching. Journal of Nanoelectronics and Optoelectronics 7, 602-606 (2012).

11. A. V. Pavlikov, I. A. Gayduchenko, G. K. Mussabek, E. T. Taurbaev, T. I. Taurbaev, V. Yu. Timoshenko. Optical and Electrical Properties of Nanocrystalline Films Formed from Amorphous Silicon by Thermal Annealing and Stain Etching Journal of Nanoelectronics and Optoelectronics 7, 629-632 (2012).

12. L.A. Aslanov, V.N. Zakharov, A.V. Pavlikov, S.V. Savilov, V.Yu Timoshenko, A.Y. Yatcenko. Synthesis and properties of nanosilicon stabilized by buthyl and perfluorobuthyl ligands. Koordinatsionnaya Khimiya, 39(5):345-352 (2013).

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