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National Cancer Institute, Vilnius/Lithuania

 

Prof. habil. Dr. Ricardas Rotomskis

National Cancer Institute

Laboratory of Biomedical Physics

Santariškių 1 LT-08660 Vilnius, Lithuania

Email: ricardas.rotomskis(at)nvi.lt

Professor, habil.dr. Ricardas Rotomskis

Head of the Biomedical Physics Laboratory (2004) of National Cancer Institute & Professor (2000) at the Department of Quantum Electronics, Vilnius University, Lithuania.

Member of European Society for Photobiology (ESP), member of Vilnius University Studies Committees for the education in Biophysics and Medical physics, head of Biophysics studies committee at Physics Faculty, a member of Lithuanian Doctoral studies committees for Biophysics, member of Mirror Group of the European Technology platform “NanoMedicine” representing Lithuania, a member of the LALS International Advisory Board, an expert of Lithuanian Ministry of Education and Science, Lithuanian Science Council, Lithuanian Science, Innovation and Technology Agency, and Singapore National Medical Research Council. A member of Lithuanian Science Avard Committee since 2012. 

Education

MSc in Solid state physics, Faculty of Physics, Vilnius University, Vilnius, Lithuania (1976), PhD in Biophysics, M.V.Lomonosov State University, Moscow, (Russia) (1985). Habilitation thesis (Applied physics) Vilnius University, Vilnius, (Lithuania) (1998).

Professional experiences

Professor of Vilnius University, Vilnius, (1999- present); Head of the laboratory of Biomedical Physics at National Cancer Institute, (2004 –present); Deputy Director of Strategy and Science at Institute of Oncology Vilnius University (2008-2010); Associate Professor at the Department of Quantum Electronics of Physics Faculty of Vilnius University, Vilnius, (1994-1999); Senior scientist at the Department of Quantum Electronics of Vilnius University, Vilnius. (1985-1994); Postdoctoral work in the Photosynthesis Department of Huigens Laboratory of Leiden University, Leiden, The (1987-1988); Doctoral student at the Biophysics Department of M.V.Lomonosov Moscow State University, Moscow, (1982-1985).

Training and Research, Management and Administration

Fields of training and research, management and administration experience (last 10 years):

2001-2005 - project “Cell Biology and Lasers: Towards New Technologies” financed by European Commission Research Directorates General in the Framework of the Specific Research and Technological Development Programme “Confirming the international role of Community Research”- scientific adviser of work packages of the project. Planning and managing of common experiments in Oslo University (Oslo, Norway), Krakow University (Krakow, Poland), Greningen University (Greningen, The Netherlands).

2002-2007 – visiting professor at Oslo University (Oslo, Norway), Krakow University (Krakow, Poland), Greningen University (Greningen, The Netherlands) Project “Cell Biology and Lasers: Towards New Technologies” funded by European Commission Research Directorates General in the Framework of the Specific Research and Technological Development Programme.

2004-2007 - the project “Digital compendium: innovative learning materials for remote tutoring”, funded by EC Leonardo da Vinci programme - coordinator. 

2005 - research project “Investigation of selective accumulation of the sensitizer in the inflamed joint” financed by the Lithuanian State Science and Studies Foundation -a project leader.

2006 - research project “Experiments in model systems: towards selective fluorescence detection from deep layers of the tissue” financed by the Lithuanian State Science and Studies Foundation -a project leader.

2006-2008 – the project of Vilnius University, Kaunas Medical University, Kaunas Medical University Clinic, KMU Biomedical Institute, Vilnius University Institute of Eksperimental and Clinical Medicine, Lithuanian Oncology Center, Lithuanian Center of Phatology, Vilnius University Institute of Imunology “The center of medical physics and nanophotonics” funded by European structural funds – a project leader.

2008-2010 Open European Funds “Norway grants“ Project, “Multifuntional nanoparticles for noninvasive early cancer diagnostic and therapy” a project leader.

2010 – 2011 National scientific program “Cancer stem cells markers for noninvasive diagnostic and therapy”. Nr.LIG-10046 a project leader.

2008-2012 Project “EUROpean network of trans-national collaborative RTD projects in the field of NANOMEDicine” (7 BP –ERA-NET iniciative: “EuroNanoMed Net“) a project leader from Lithuania.

2013-2015 EU funds Project “Use of cells programming and tumor microenvironment control for individualized patient’s therapy in oncology (LASTER)“, a project leader.

2012-2015. National Integrated Programmes; Project “Biotechnology and biopharmacy: fundamental and applied research”, , a project leader

2014-2016 Mutual Funds Taiwan – Latvia – Lithuania Project “Mesenchymal stem cell and cancer stem-like cell response to nanoparticle treatment”, No. TAP LLT 03/2014, a project leader from Lithuania. 

A member of European Society for Photobiology (ESP) Council, responsible for the activities in East Europe, member of Vilnius University Studies Committees for the education in Biophysics and Medical physics, head of Biophysics studies committee at Physics Faculty, a member of Lithuanian Doctoral studies committees for Biophysics, member of Mirror Group of the European Tecnhnology platform “NanoMedicine” representing Lithuania, a member of the LALS International Advisory Board, an expert of Lithuanian Science Council and Singapore National Medical Research Council. Also serve as reviewers for journals, including Journal photochemistry and photobiology B: Biology, JACS.

Dr.Theodore Maiman Award at SPIE's International Biomedical Optics'93 Symposium in Los Angeles (USA) in 1993. Lithuanian Science Award in 2002.

Relevant activities in the field of thematic area

Leader of the scientific group prof. Ričardas Rotomskis has many years lasting experience in the preparation and implementation of both national and international projects. Currently his activities include investigations of photosensitized tumor diagnosis and therapy processes, studies on topics of biophotonics, interaction of optical radiation with biological objects, characterizations of the spatial and photophysical properties of nanoparticles and investigations of their accumulation and distribution in different cell lines and experimental animals. He is managing the experimental investigations on steady-state and kinetic spectroscopy of biological objects, studies of photophysical parameters of nanostructures and photosensitizers under optical two-photon excitation. His scientific activities are concentrated on the investigations of primary photophysical and photochemical processes and photostability of sensitizers, quantum dots, gold nanoclusters, up-converting nanoparticles related to the photochemotherapy, optical biopsy of cancer in vivo and in vitro.

Relevant publications in the field of thematic area

Main scientific interests: biophysics, biomedical physics, nanophotonics, biophotonics, nanomedicine, lasers application in life sciences and spectroscopy, photophysics and photochemistry of biologically active molecules in model and biological environment, lasers application in life sciences particularly those used in photosensitized tumour therapy; fluorescence methods in biomedical diagnostics and visualization; biomedical applications of nanotechnologies etc. Co-authored over 300 papers and reports (since 1990 over 100 papers in Web of Science, sum of the times cited-681, h-index-14), 2 monographs, 8 textbooks were published with co-authors in nanomedicine, optical tumor diagnostics (optical biopsy), photosensitized tumor therapy, studies of nanoparticle synthesis and its optical, photophysical, photochemical properties.

  1. Matulionytė M., Marcinonytė R., Rotomskis R., Photoinduced spectral changes of photoluminescent gold nanoclusters, Journal of Biomedical Optics 20(5), 2015.
  2. Jurga Valanciunaite, Andrey S. Klymchenko, Artiom Skripka, Ludovic Richert, Simona Steponkiene, Giedre Streckyte and Ricardas Rotomskis A non-covalent complex of quantum dots and chlorine e6 : efficient energy transfer and remarkable stability in living cells revealed by FLIM, RSC Advances 4(94): 52270-52278, 2014.
  3. Steponkiene S, Valanciunaite J, Skripka A, Rotomskis R. Cellular uptake and photosensitizing properties of quantum dot-chlorin e6 complex: in vitro study. J Biomed Nanotechnol., 10(4):679-86, 2014.
  4. Kulvietis V., Zurauskas E., Rotomskis R. Distribution of polyethylene glycol coated Quantum dots in mice skin. Exp. Dermatology, 22(2):157-159, 2013.
  5. Stalnionis M., Matulionyte M., Rotomskis R., 99Tc-Au-BSA fluorescenct nanoclusters as potential multimodal imaging agents European Journal of Nuclear Medicine and Molecular Imaging 40(suplement2) :S284-S284, 2013.
  6. Skripka A., Valanciunaite J., Dauderys G., Poderys V., Kubiliute R., Rotomskis R., Two-photon excited quantum dots as energy donors for photosensitizer chlorine e(6), Journal of Biomedical Optics, 18(7):DOI 10 1117/1 JBO 18.7.078002, 2013.
  7. Rudys R., Kirdaite G., Bagdonas S., Leonaviciene L., Bradunaite R., Streckyte G., Rotomskis R., Spectroscopic assessment of ebdogeneous porphyrins in a reheumatoidic arthritis rabit model after application of ALA and ALA-Me, Journal of Photochem. Photobiol.;B, 119;15-21, 2013.
  8. Kubiliute R., Maximova K.A., Lajevardipour A., Yong J., Hartley J.S., Mohsin A.S.M., Blandin P., Chon J.V.M., Sentis M., Stoddard P.R., Kabashin A. Rotomskis R., Clayton A.H.A., Andrew H.A., Juodkazis S., Ultra-pure water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation, Int. J. Nanomedicine, 8:2601-2611, 2013.
  9. Venius J., Zurauskas E., Rotomskis R. High resolution imaging of the human cardiac conduction system using reflectance confocal microscopy Tohoku Journal of Eksperimental Medicine 229(1):67-73, 2013
  10. Kulvietis V., Zalgeviciene V., Didziapetriene J., Rotomskis R. Transport of nanoparticles through placental barrier, Tohoku Journal of Experimental Medicine, 225(4):225-234, 2011.
      

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